All treated materials presented strong shrinkage, fiber orientation loss, and collapsed fibers. Suitable degradation behavior without pH variations was observed for all samples up to 28 days. A decrease of contact angle and greater cell adhesion to hydrolyzed, FN-coated PLGA scaffolds were noticed. FN coating was evidenced by X-ray photoelectron analysis. Then, hydrolyzed scaffolds were coated by simple deposition of an FN layer (10 μg/mL). Functionalization of electrospun PLGA scaffolds was performed by alkaline hydrolysis (0.1 or 0.01 M NaOH). Here, to overcome it, we have developed a fibronectin (FN)-functionalized electrospun PLGA scaffold for periodontal ligament regeneration. ![]() Despite the current use of bioresorbable polyesters such as poly( l-lactide) (PLA), poly( d,l-lactide- co-glycolide) (PLGA), and poly-ɛ-caprolactone in soft tissue regeneration researches, their hydrophobic properties negatively influence the cell adhesion. Nowadays, the challenge in the tissue engineering field consists in the development of biomaterials designed to regenerate ad integrum damaged tissues.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |